-- LilyHong - 14 Apr 2009

You are invited to attend a statistics seminar and dinner hosted by The
Applied Biostatistics Association (TABA).

Topic: Cluster Randomization Trials in Health Research: An Introduction to Design and Analysis

Please RSVP for both the seminar and dinner to Tina Haller, TABA Treasurer, at taba.exec@gmail.com

by February 6, 2003. Reservations for the dinner are required by February 6th.

A cheque for dinner can be made payable to TABA and forwarded to Tina Haller
at 6 Matson Dr. RR#2, Bolton ON, L7E 5R8.

A business meeting for TABA will follow the dinner. The agenda includes a
review of TABA's finances and discussion about elections for the TABA
executive. Anyone interested in participating in the TABA executive,
please contact TABA president, Jamie Myles at
jamie.myles@pharmacia.com

WHEN: Tuesday February 11, 2003
seminar at 5:30
dinner to follow talk

WHERE:
15'th floor boardroom of Cancer Care Ontario, 620 University Ave
(NOTE: This is a new location!)
Cancer Care Ontario is adjacent to PMH.

COST: seminar - FREE
dinner - $15 / non-student $5 / student


SPEAKER: Dr. Neil Klar from the Division of Preventive Oncology at Cancer
Care Ontario

ABSTRACT

It is becoming increasingly common for health researchers to consider
randomizing intact social units (e.g. families, schools, communities) rather
than independent individuals in experimental trials. Reasons are diverse,
but include administrative convenience, a desire to reduce the effect of
treatment contamination and the need to avoid ethical issues which might
otherwise arise. Dependencies among cluster members typical of such designs
must be considered when determining sample size and analysing the resulting
data. Failure to adjust standard statistical methods for within-cluster
dependencies may result in severely underpowered studies and in spuriously
elevated Type I error rates. The purpose of this talk is to review the key
issues in the design and analysis of cluster randomization trials. These
ideas will be illustrated using data from several recently completed
studies.